Health.am| Table 46-1 Cytochrome P450 (CYP) biotransformation reactions | |||
| Enzymes | Substrates | Inhibitors | Inducers |
| CYP1A2 | Amitriptyline |
Ciprofloxacin | Nicotine |
Caffeine | Enoxacin | Omeprazole | |
Clomipramine | Erythromycin | Phenobarbital | |
Haloperidol | Fluvoxamine | Phenytoin | |
Imipramine |
Furafylline | Rifampin | |
Propranolol | Grapefruit juice | ||
R-warfarin | Quinolones | ||
|
Theophylline | |||
Verapamil | |||
CYP2C9 | Nonsteroidals | Fluconazole | Phenobarbital |
Phenytoin | Fluvoxamine | Rifampin | |
S-warfarin | Ketoconazole | ||
Tolbutamide | Metronidazole | ||
Ritonavir | |||
Sulfaphenazole | |||
CYP2C19 | Clomipramine | Fluoxetine |
Phenobarbital |
Diazepam | Ritonavir | Rifampin | |
Hexobarbital | Sertraline | ||
Imipramine | |||
Mephenytoin | |||
Omeprazole | |||
Propranolol | |||
S-mephenytoin | |||
CYP3A4/4/5 | Alprazolam | Anastrozole | Carbamazepine |
Amiodarone | Cimetidine | Dexamethasone | |
Astemizole | Diltiazem |
Phenobarbital | |
Carbamazepine | Erythromycin | Pentobarbital | |
Cisapride | Fluconazole | Phenytoin | |
Clozapine | Fluvoxamine | Rifabutin | |
Cortisol | Indinavir |
Rifampin | |
Cyclosporin | Itraconazole | Troglitazone | |
Dapsone | Ketoconazole | ||
Dextromethorphan | Mibefradil | ||
Dihydropyridine | Miconazole | ||
Calcium channel blockers | Nefazadone | ||
|
Digitoxin | Nelfinavir | ||
Diltiazem | Quinidine | ||
Erythromycin | Ritonavir | ||
Ethinyl estradiol | Troleandomycin | ||
Ethosuximide |
Verapamil | ||
Felodipine | |||
Fluvoxamine | |||
Imipramine | |||
Indinavir | |||
Lansoprazole | |||
Lidocaine | |||
Losartan | |||
Lovastatin | |||
Nicardipine | |||
Nifedipine | |||
|
Nelfinavir | |||
Progesterone | |||
Propafenone | |||
Quinidine | |||
Saquinavir | |||
Simvastatin | |||
Tacrolimus | |||
Tamoxifen | |||
Terfenadine | |||
Testosterone | |||
Triazolam | |||
Verapamil | |||
Warfarin | |||
CYP2D6 | Amitriptyline | Amiodarone | |
Astemizole | Amitriptyline | ||
Carvedilol |
Cimetidine | ||
Clomipramine | Clomipramine | ||
Codeine | Fluconazole | ||
Debrisoquine | Fluoxetine | ||
Desipramine | Fluphenazine | ||
Doxepine | Fluvoxamine | ||
|
Flecainide | Haloperidol | ||
Fluoxetine | Nefazadone | ||
Haloperidol | Perphenazine | ||
Imipramine | Paroxetine | ||
Metoprolol |
Quinidine | ||
Mexiletine | Ritonavir | ||
Nortriptyline | Sertraline | ||
Paroxetine | Thioridazine | ||
Penbutolol | Venlafaxine | ||
Perphenazine | |||
Propafenone | |||
Risperidone | |||
Sparteine | |||
Thioridazine | |||
Timolol | |||
Trazodone (mCPP metabolite) | |||
Venlafaxine | |||
Verapamil | |||
Note. mCPP = m-chlorophenylpiperazine. | |||
Source. Adapted from Tanaka 1998, Callahan et al. 1996, and Schaiff 1998. | |||