Table 45-7 Efficacy of standard anticonvulsants in bipolar depression in double-blind trials (reporting results of at least eight bipolar subjects)
| Table 45-7 Efficacy of standard anticonvulsants in bipolar depression in double-blind trials (reporting results of at least eight bipolar subjects) | ||||
| Improvement, % | ||||
| Drug | Investigator | N | Responders | Nonresponders |
| Carbamazepine | Ballenger and Post 1978 | 9 | 44 | 56 |
| Post et al. 1984 | 25 |
48 | 52 | |
Lamotrigine | Frye et al. 2000 | 38 |
45 | 55 |
Calabrese et al. 1999 | 195 | |||
At 200 mg/day | 51 | 49 | ||
At 50 mg/day | 41 | 59 | ||
Gabapentin | Frye et al. 2000 | 38 | 27 | 73 |
Note. Case reports and case series that did not include all consecutive patients treated with a novel anticonvulsant were excluded from this table. | ||||