Table 45-5 Clinical trials of antidepressants in the treatment of bipolar depression
| Table 45-5 Clinical trials of antidepressants in the treatment of bipolar depression | |||||||
| Concurrent treatment | |||||||
| Investigators | Placebo | Drug 1 | Drug 2 | Results | Antipsychotic | Lithium | Treatment-emergent mania? |
| Fieve et al. 1968 | No | Lithium (n = 17) | Imipramine (n = 12) | Imipramine > lithium | — | No | ? |
| Kessell and Holt 1975 | No | Maprotiline (n = 9) | Imipramine (n = 5) | Imipramine = maprotiline | ? | ? | ? |
| Merideth and Feighner 1983 | Yes (n = 19) | Bupropion (n = 30) | — | Bupropion > placebo | ? | ? | ? |
| Fabre et al. 1983 | Yes (n = 27) | Bupropion (n = 48) | — | Bupropion > placebo | ? | ? | ? |
| Baumhackl et al. 1989 | No | Moclobemide (n = 17) | Imipramine (n = 15) | Moclobemide = imipramine | Allowed | No | ? |
| Cohn et al. 1989 | Yes (n = 13) | Fluoxetine (n = 21) | Imipramine (n = 21) | Fluoxetine > imipramine | Allowed | No | 1 placebo, 2 imipramine, 4 fluoxetine |
| Himmelhoch et al. 1991 | No | Tranylcypromine (n = 28) | Imipramine (n = 28) | Tranylcypromine > imipramine | No | No | 6 tranylcypromine, 7 imipramine |
| Sachs et al. 1994a | No | Bupropion (n = 9) | Desipramine (n = 10) | Bupropion = desipramine | Yes | No | 5 desipramine, 1 bupropion |
| Note. "—" indicates not applicable; "?" indicates not reported. | |||||||