Table 39-3 Clinical situations in which antidepressant medication treatment is usually required

MDE with moderate to severe symptoms
MDE with potential for suicide or other harmful consequences
MDE with psychotic features (antipsychotic or ECT usually required)
MDE with melancholia
MDE in a patient for whom maintenance treatment is planned or relapse is likely
MDE in a patient with bipolar disorder (concomitant antimanic drug usually required)
MDE in a patient with prior history of:
Major depressive disorder
Poor interepisode recovery
Prior medication response
Failure to respond to psychotherapy
MDE in a patient with obsessive-compulsive disorder or panic disorder


Note. MDE = major depressive episode; ECT = electroconvulsive therapy.