Table 39-10 Dose titration for antidepressant and antimanic drugs

Table 39-10 Dose titration for antidepressant and antimanic drugs
Drug type	Usual dosing	Titration to therapeutic dosage
TCAs	hs or bid	7-14 days
MAOIs	A.M. or bid	7-14 days
RIMAs	A.M. or bid	7-14 days
SSRIs	A.M.	0-7 days
Bupropion	tid	7-14 days
Venlafaxine	A.M. or bid	7-14 days
Nefazodone	bid	7-14 days
Mirtazapine	hs	0-14 days
Reboxetine	bid	0-7 days
Monoamine-releasing agents	A.M.	0-14 days
Lithium	hs or bid	0-7 days
Divalproex sodium	bid or tid	7-14 days
Carbamazepine	bid or tid	7-14 days
Lamotrigine	bid	14-28 days
Gabapentin	bid or tid	7-21 days
Topiramate	hs	21-64 days
Note. TCAs = tricyclic antidepressants; MAOIs = monoamine oxidase inhibitors; RIMAs = selective reversible inhibitors of MAO-A; SSRIs = selective serotonin reuptake inhibitors.