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Table 14.5. Criteria used to recognize teratogens in humans

Table 14-5. Criteria used to recognize teratogens in humans.
Abrupt increase in the incidence of a particular defect or association of defects
Known environmental change coincident with this increase.
Known exposure to the environmental change early in pregnancy, yielding characteristically affected infants.
Absence of other factors common to all pregnancies, yielding infants with the characteristic defects.
Modified and reproduced, with permission, from Wilson JG: Embryotoxicity of drugs in man. In: Handbook of Teratology. Vol 1. Wilson JG, Fraser FC (editors). Plenum Press, 1977.