TABLE 419-2 -PROPHYLAXIS OF OPPORTUNISTIC INFECTIONS
| INFECTION | AVAILABLE AGENTS | COMMENTS |
| Pneumocystis carinii pneumonia | SMX-TMP Dapsone Atovaquone Aerosolized pentamidine |
SMX-TMP most effective and least expensive but potentially toxic |
| Mycobacterium avium complex (MAC) | Rifabutin Azithromycin Clarithromycin |
Delay in disseminated MAC infection; potential pharmacokinetic interactions with protease inhibitors and zidovudine; resistant isolates possible |
| Toxoplasmic encephalitis | SMX-TMP Dapsone-pyrimethamine | |
| Cryptococcal meningitis | Fluconazole | Delay in deep fungal infections but costly; resistant isolates possible |
| Cytomegalovirus | Oral ganciclovir | Delay in CMV disease but costly |
SMX-TMP = Sulfamethoxazole-trimethoprim.