TABLE 412-3-FEATURES OF TUBERCULOSIS IN PATIENTS WITH HIV INFECTION
| EARLY IN HIV DISEASE | LATE IN HIV DISEASE | |
| Clinical course | More indolent Fewer systemic symptoms/signs |
More acute Systemic symptoms/signs may predominate |
| Sites of disease | Predominantly pulmonary | Predominantly extrapulmonary and disseminated |
| Chest film | Upper lobe cavitary lesions | Diffuse or lower lobe infiltration Adenopathy Occasionally normal when lungs involved |
| Tuberculin test | Usually positive | Usually negative |
| Sputum smear/culture | Usually positive | Usually positive in patients with pulmonary disease |
| Infectiousness | Infectious when lungs are involved | Infectious when lungs are involved |
| Response to therapy | Excellent | Excellent |