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TABLE 19-3 - Association between the presence of various HLA markers and selected autoimmune diseases




































Disease Associated HLA Marker1 Relative Risk of Disease2
Ankylosing spondylitis B27 87.4
Reactive arthropathy, including Reiter's syndrome B27 37.0
Rheumatoid arthritis DR4 4.2
Behcet's syndrome B51 3.8
Systemic lupus erythematosus DR3 5.8
Insulin-dependent (type 1) diabetes mellitus DR3
DQB1*0201
  DR4
DQB1*0302 
DR2 
DRB*15013
DRB*01013
DQB1*06023		 3.3
2.4
6.4
9.5
0.19


0.15
Idiopathic Addison's disease DR3 6.3
Graves' disease DR3 3.7
Hashimoto's disease DR11 3.2
Postpartum thyroiditis DR4 5.3
Celiac disease DR3
DQB1*02013
DQA1*05013
DR7,11
DR7, DQB1*0201
DR11, DQA1*0501		 10.8


6.0-10.00
Dermatitis herpetiformis

DR315.9
Sicca syndrome

DR39.7
Myasthenia gravisDR3
B8		2.5
3.4
Idiopathic membranous glomerulonephritis

DR312.0
Goodpasture's syndrome

DR215.9
Multiple sclerosis

DR2
DRB1*15013
DRB5*01013
DQB1*06023		4.1
Pemphigus vulgaris (among Ashkenazi Jews)

DR414.4
Psoriasis vulgaris

CW613.3
Birdshot retinochoroidopathyA29109.0

Reproduced, with permission, from Klein J et al: The HLA system. First of two parts. N Engl J Med 2000;343:782.

1Symbols with asterisks indicate alleles, and symbols without asterisks indicate serologically defined antigens. For each disease, the marker or markers with the strongest associations are given. In many cases in which it is difficult to decide whether HLA-DR or -DQ markers are responsible for association, both markers are given.

2The relative risk indicates the frequency of a disease in persons with the HLA marker as compared with persons without the marker. A positive association (ie, when the HLA marker is more frequent in persons with the disease than in those without it) is indicated by a relative risk of more than 1.0, a negative association by a relative risk of less than 1.0, and no association by a relative risk of 1.0.

3The risk has not been assessed separately for this allele.