TABLE 90-28
| Table 90-28. Randomized Trials for Laryngeal Preservation | |||||
Site |
Treatment |
Trial Size |
3-Year Laryngeal Preservative Rate (%) |
Survival Rate |
Author |
Glottis and |
PF→RT |
332 |
66* |
53% at 3 y |
VACSP(L43) |
Supraglottis |
S→RT |
56%at 3 y |
|||
Hypopharyn |
PF→RT |
202 |
28 |
57% at 3 y |
Lefebvre et al. |
x and lateral epilarynx |
S→RT |
43% at 3 Y |
(L46) |
||
Hypopharyn |
PF→RT |
91 |
NR |
19% at 5 y* |
Mahe et al. |
x |
PF→S→RT |
37% at 5y* |
(L44) |
||
Glottis and |
PF→RT |
547 |
58 |
NS |
Forastiere et al. |
Supraglottis |
P + RT |
66 |
(L45) |
||
RT |
52 |
||||
| P = cisplatin; F = 5-fluorouracil; S = surgery; RT = radiotherapy; NR = not reported; NS = not significant. | |||||
| * P<.05. | |||||