Table 33.12. Hormonal agents currently considered in postmenopausal women with breast cancer
| Table 33.12. Hormonal agents currently considered in postmenopausal women with breast cancer. | ||
| Class | Agents | Principal toxicities |
| Estrogen antagonists |
Tamoxifen Toremifene |
Hot flashes, vaginitis Rarely, endometrial cancer, venous thrombosis |
| Aromatase inhibitors |
Anastrozole Letrozole Exemestane |
Hot flashes, gastrointestinal distress |
| Progestins | Megestrol acetate |
Weight gain, fluid retention Rarely, venous thrombosis |
| Androgens | Fluoxymesterone | Masculinizing effects |