TABLE 142-1. CHROMOSOMAL ABNORMALITIES ASSOCIATED WITH HUMAN CANCERS
| TABLE 142-1. CHROMOSOMAL ABNORMALITIES ASSOCIATED WITH HUMAN CANCERS | |
| Type of Cancer | Chromosomal Abnormality |
|
Myeloid leukemia Chronic myelocytic leukemia Acute myelogenous leukemia with maturation Acute promyelocytic leukemia Acute nonlymphocytic leukemia with increased basophils Acute monocytic leukemia Acute myelomonocytic leukemia with eosinophilia Therapy-related acute myelogenous leukemia |
t(9;22) t(8;21) t(15;17) t(6;9) 11q- inv16 -7 or del(7q) or -5 or del(5q) |
|
Malignant lymphoma Burkitt's Non-Hodgkin's |
t(8;14) t(14;18), t(11;14) |
|
Lymphocytic leukemia Acute lymphoblastic leukemia Chronic lymphocytic leukemia |
t(1;19), t(8;14), t(8;22) t(11;14), t(14;19), t(2;14), +12 |
| Myeloproliferative diseases | +1 |
|
Solid tumors Adenocarcinomas Small cell lung cancer Kidney Uterus Prostate Bladder Ovary Colon Sarcomas Liposarcoma, myxoid Synovial sarcoma Rhabdomyosarcoma (alveolar) Extraskeletal myxoid chondrosarcoma Ewing's tumor Peripheral neuroepithelioma Miscellaneous Testicular and ovarian dysgerminoma Retinoblastoma Wilms' tumor Neuroblastoma Malignant melanoma Mesothelioma |
3p- 3p- 1q- 10q- 19 or inv9, 11, 5 t(6;14) 17q-, 18p- t(12;16) t(X;18) t(2;13) t(9;22) t(11;22) t(11;22) inv12 13q- 11p- 1p- 6q- or inv6 3p- |
| t = translocation; q = long arm of the chromosome; inv = inversion; p = short arm of the chromosome; - = deletion; + = extra chromosome. | |