Table 118-2. Putative Tumor Suppressor Genes In Epithelial Ovarian Cancer
| Table 118-2. Putative Tumor Suppressor Genes In Epithelial Ovarian Cancer | ||
|
Gene |
Chromosome Location |
Function |
| SPARC | 5q31 | matrix |
| Dab2 | 5p13 | binds GRB2 |
| PTEN (MMAC-1) | 10q23 | phosphatase |
| NOEY2 | 1p31 | induces p21, inhibits cyclin D1 |
| p53 | 17p13 | DNA stability, apoptosis |
| LOT-1 | 6q25 | zinc finger |
| OVCA1 | 17p13 | unknown |
| BRCA1a | 17q21 | DNA repair |
| BRCA2a | 13q12 | DNA repair |
| Adapted from Bast RC Jr, Mills GB.75 | ||
| aPredominantly in hereditary ovarian cancer. | ||