TABLE 375-2 - Interactions of Smoking and Prescription Drugs
| Drug | Interaction |
| Benzodiazepines | Less sedation |
| Beta blockers | Reduced lowering of heart rate and blood pressure |
| Caffeine | Faster metabolic clearance |
| Chlorpromazine | Decreased serum concentrations * |
| Clomipramine | Decreased serum concentrations * |
| Clozapine | Decreased serum concentrations * |
| Dextropropoxyphene | Less analgesia |
| Oral estrogens | Increased hepatic clearance |
| Flecainide | Increased first-pass clearance |
| Fluphenazine | Decreased serum concentrations * |
| Fluvoxamine | Decreased serum concentrations * |
| Haloperidol | Decreased serum concentrations * |
| Heparin | Faster clearance |
| Imipramine | Decreased serum concentrations * |
| Insulin | Delayed absorption due to skin vasoconstriction |
| Lidocaine | Increased first-pass clearance |
| Mexiletine | Increased first-pass clearance |
| Olanzapine | Faster clearance |
| Pentazocine | Less analgesia, possibly increased clearance |
| Propranolol | Increased first-pass clearance |
| Tacrine | Faster metabolic clearance |
| Theophylline | Faster metabolic clearance |
| Thiothixene | Faster metabolic clearance |
| Trazodone | Decreased serum concentrations * |
* Clinical implication uncertain