Mood: depressed mood most of the day, nearly every day
Sleep: insomnia or hypersomnia
Interest: marked decrease in interest and pleasure in most activities
Guilt: feelings of worthlessness or inappropriate guilt
Energy: fatigue or low energy nearly every day
Concentration: decreased concentration or increased indecisiveness
Appetite: increased or decreased appetite or weight gain or loss
Psychomotor: psychomotor agitation or retardation
Suicidality: recurrent thoughts of death, suicidal ideation, suicidal plan, suicide attempt
General criteria for a major depressive episode require five or more of the above symptoms to be present for at least 2 weeks; one symptom must be depressed mood or loss of interest or pleasure. These symptoms must be a change from prior functioning and cannot be due to a medical condition, cannot be substance-induced, and cannot be due to bereavement. The symptoms must also cause distress or impairment. Reprinted with permission from the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision. Copyright 2000 American Psychiatric Association.