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TABLE 13-3 - Common Mood Stabilizers

Drugs Starting Dosage Therapeutic Dosage Therapeutic Serum Concentration
Lithium carbonate 300 mg bid-tid 900-1500 mg/day 0.6- 1.1 mEq/L
Valproic acid 250 mg bid-tid 1000-2500 mg/day 50- 120 mg/L
Carbamazepine 100 mg bid-tid 600-1200 mg/day 4-12 mg/L
Lamotrigine 25-50 mg qhs 2 300-500 mg/day -
Gabapentin 300 mg qd 900- 1800 mg/day -
Oxcarbazepine 150mgbid 600-1200 mg/day -

1 Dosages are generally lower for geriatric patients, patients taking interacting medications, or patients with other medical problems.

2 valproate will increase lamotrigine serum level, necessitating lower dosages.

Adapted from Stoll AL, Psychopharmacology reference card, 1996 and from Physician's desk reference, S6th ed.2002.