Pregnancy hormone key to repairing nerve cell damage

The mystery of why multiple sclerosis (MS) tends to go into remission while women are pregnant may be the secret to overcoming the devastating neurodegenerative disease, according to University of Calgary researchers who have shown that a pregnancy-related hormone is responsible for rebuilding the protective coating around nerve cells.

In a paper to be published in the February 21 issue of The Journal of Neuroscience, a team of researchers from the U of C's Faculty of Medicine reports that a study conducted on mice found that the hormone prolactin encourages the spontaneous production of myelin, the fatty substance that coats nerve cells and plays a critical role in transmitting messages in the central nervous system. A collaboration between the laboratories of Drs. Samuel Weiss and V. Wee Yong of the Hotchkiss Brain Institute, the study is the first to determine that prolactin, which increases in the body during pregnancy, is directly responsible for the formation of new myelin in the brains and spinal cords of pregnant mice. Further, when non-pregnant mice with MS-like lesions were injected with prolactin, their myelin was also repaired.

The research was based on evidence that MS, which is more common in women than men, goes into remission when women become pregnant. MS is a neurodegenerative disease where the body's own immune system attacks the myelin surrounding nerves, leading to progressive loss of sensation and movement. MS affects approximately 2.5 million people worldwide and Canadians have one of the highest rates of the disease in the world.

"It is thought that during pregnancy, women's immune systems no longer destroyed the myelin," said Weiss, director of the Hotchkiss Brain Institute and senior author of the study. "However, no previous study has tested whether pregnancy actually results in the production of new myelin, which may lead to improvement of symptoms." The paper's findings represent the first example of a natural, biological mechanism that produces new myelin in the adult brain and spinal cord and identifies prolactin as a potential therapeutic substance for future testing in people with MS.

"Agents promoting remyelination will be beneficial not only for typical demyelinating diseases like MS," says Dr. Fred (Rusty) Gage, of the Salk Institute, "but also for many other neurological disorders, such as spinal cord injuries and stroke." Gage, an international leader in nervous system repair, was not involved in this study.

Subsequent tests of prolactin in animal models of MS will be required before testing of prolactin on humans can take place, but MS researchers are hopeful human trials can take place within the next several years.

"This discovery has the potential to take MS therapy a step further than current treatments that stabilize the disease in its early stages. By promoting repair, which is the goal of prolactin therapy, we have hope of actually improving symptoms in people with MS," says Dr. Luanne Metz, director of the Calgary MS Clinic in the Department of Clinical Neurosciences, University of Calgary and Calgary Health Region.