Radioactive iodine uptake
Key points
- Radioactive Iodine Uptake, or RAIU, is a test of thyroid function.
- RAIU is a type of nuclear test of the thyroid that measures how much radioactive iodine is taken up by the thyroid gland in a given time period.
- Consult with the health care provider if you have a history of factors that may affect the test (see "special considerations").
- You can eat beginning about 1 to 2 hours after ingesting the radioactive iodine, and you can resume a normal diet when the test is finished.
Alternative names
Iodine uptake test; RAIU
Definition
Radioactive Iodine Uptake, or RAIU, is a test of thyroid function. The amount of orally ingested radioactive iodine that accumulates in the thyroid gland is measured.
How the test is performed
RAIU is a type of nuclear test of the thyroid that measures how much radioactive iodine is taken up by the thyroid gland in a given time period. You are asked to ingest radioactive iodine (I-123 or I-131) in liquid or capsule form. After a time (usually 6 and 24-hours later), you must return to have the radioactivity measured.
A probe (gamma probe) is placed over the thyroid gland in the neck to measure the amount of radioactivity in the thyroid gland. This amount of radioactivity is compared with the original dose of radioactivity and reported as a percent of the original dose.
How to prepare for the test
Fast for 8 hours before the test.
Consult with the health care provider if you have a history of factors that may affect the test (see "special considerations"). The health care provider may restrict iodine and thyroid (or anti-thyroid) medications for 1 week before the test.
How the test will feel
There is no discomfort. You can eat beginning about 1 to 2 hours after ingesting the radioactive iodine, and you can resume a normal diet when the test is finished. For the scanning, you are asked to lie on a table while the scanner is placed over the neck. The scan takes about 30 minutes.
Why the test is performed
This test is performed to evaluate thyroid function, particularly when blood tests of thyroid function (for example, T3 or T4 levels) have abnormal results.
Normal Values
- 6 hours: 3 to 16%
- 24-hours: 8 to 25%
Note: Some laboratories only measure at 24-hours. There may be some variation in values with dietary iodine ingestion and with laboratory procedural differences.
What abnormal results mean
Increased (greater than 35% at 24-hours is considered elevated):
- hyperthyroidism
- Hashimoto's thyroiditis (early)
- goiter
Decreased:
Written and revised by
David Cohen, M.D.
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