Necrotizing vasculitis

Alternative names

Vasculitis - necrotizing

Definition

Necrotizing vasculitis is an inflammatory condition of blood vessels characterized by tissue death, scarring, and proliferation of the walls of the blood vessels, which may result in blockage of the vessel.

Causes, incidence, and risk factors

Necrotizing vasculitis is rare. It may occur in rheumatoid arthritis and is commonly seen with systemic lupus erythematosus, polyarteritis nodosa, and progressive systemic sclerosis. It is very rare in children.

The disorder involves inflammation of the walls of the blood vessels. The cause of the inflammation is unknown, but is likely related to autoimmune factors. The tissues become necrotic (dead). The wall of the vessel may scar and thicken. The vessel may close off (occlude), causing lack of blood flow to the tissues supplied by that blood vessel with subsequent infarction (tissue death) of the tissues.

Necrotizing vasculitis may affect any blood vessel of the body, and therefore any part of the body, including the muscles, nerves, kidneys, liver, or any other area.

Symptoms

• Skin lesion
  o Papule (small, solid, and raised lesion)
  o Lesions red or purple (purpuric)
  o Lesions on the legs, hands, or other areas
  
• Fingers that change color (blueness of the fingers or toes)
  
• Infarction (inflammation due to lack of oxygen)
  o Pain or tenderness in the area
  o Redness (if superficial area)
  
• Joint pain (such as, knee pain, elbow pain)
  
• Abdominal pain
  
• Pain, numbness, tingling in an extremity or any area
  
• Changes or decrease in function of an extremity or any area
  
• Fever
  

Additional symptoms that may be associated with this disease:

• Weakness
  
• Swallowing difficulty
  
• Speech impairment
  
• Leg pain
  
• Muscle contractions
  
• Muscle atrophy
  
• Movement, dysfunctional
  
• Menstruation, painful
  
• Hoarseness or changing voice
  
• Fatigue
  
• Pupils different size
  
• Eyelid drooping