Brain lymphoma
Key points
- A brain lymphoma is a type of malignancy (cancer).
- The cause of primary brain lymphoma is unknown, but it is more common in people between the ages of 45 and 70.
- The initial treatment is usually with corticosteroids.
- The survival of untreated primary brain lymphoma is under 2 months.
Alternative names
Primary lymphoma of the brain; Cerebral lymphoma; Primary lymphoma of the central nervous system; Lymphoma - brain
Definition
A brain lymphoma is a type of malignancy (cancer). The term "primary" in this case means the cancer seems to have originated in the brain, not spread from somewhere else in the body.
Causes, incidence, and risk factors
The cause of primary brain lymphoma is unknown, but it is more common in people between the ages of 45 and 70. Patients who are immunocompromised, such those with HIV or organ transplants, especially heart transplants, are at greater risk for primary lymphoma of the brain. In immunocompromised patients, the lymphoma is linked to Epstein Barr Virus (EBV) infection.
The incidence is rising, but primary brain lymphoma is still relatively rare.
Symptoms
- Personality changes
- Confusion
- Changes in speech
- Changes in vision
- Weakness in hands
- Numbness to hot, cold, and pain
- Headaches
- Seizures
- Hallucinations
Signs and tests
The following tests may be performed to help diagnose a primary lymphoma of the brain:
- Biopsy of the brain - shows lymphoma
- Head CT scan - shows a brain lesion
- CSF total protein - high
- CSF cell count - shows increased white blood cells or lymphoma cells
Treatment
The initial treatment is usually with corticosteroids. However, chemotherapy increases survival in many individuals up to 3-4 years, or longer. The chemotherapy is primarily high-dose methotrexate given intravenously or via the spinal cord.
Treatment of immunocompromised patients is not as successful, but is improving.
Radiation therapy used to be the main treatment for this lymphoma, but now is usually reserved for treating those patients in whom chemotherapy is not successful.
Expectations (prognosis)
The survival of untreated primary brain lymphoma is under 2 months. Treated with chemotherapy, patients often survive 3-4 years or more. About 40% of patients are alive at 5 years. In general, older patients have a worse outlook than younger patients.
Frequently asked questions
What is brain lymphoma?
A brain lymphoma is a type of malignancy (cancer). The term "primary" in this case means the cancer seems to have originated in the brain, not spread from somewhere else in the body.
What are the risk factors for brain lymphoma?
The cause of primary brain lymphoma is unknown, but it is more common in people between the ages of 45 and 70. Patients who are immunocompromised, such those with HIV or organ transplants, especially heart transplants, are at greater risk for primary lymphoma of the brain. In immunocompromised patients, the lymphoma is linked to Epstein Barr Virus (EBV) infection. The incidence is rising, but primary brain lymphoma is still relatively rare.
What are the symptoms of brain lymphoma?
- Personality changes
- Confusion
- Changes in speech
- Changes in vision
- Weakness in hands
- Numbness to hot, cold, and pain
- Headaches
- Seizures
- Hallucinations Signs and tests The following tests may be performed to help diagnose a primary lymphoma of the brain:
- Biopsy of the brain - shows lymphoma
- Head CT scan - shows a brain lesion
- CSF total protein - high
- CSF cell count - shows increased white blood cells or lymphoma cells
How is brain lymphoma treated?
Written and revised by
Andrey Nailor, M.D.
Our doctors write and review articles for accuracy and keep them up to date.
health.am provides general information, not medical advice. Always consult a qualified health professional about your own health.