Statins may be linked to cancer survival

Danish cancer patients taking cholesterol-lowering statin drugs were 15 percent less likely to die, of cancer or any other cause, than patients who were not on the popular medications, in a new study.

The pattern held regardless of a person's age, cancer type, tumor size or whether it had spread. Only patients who had received chemotherapy showed no apparent benefit from taking statins - the most commonly-prescribed drugs in the world.

Eric Jacobs, a researcher at the American Cancer Society who was not involved in the new work, called the findings "intriguing and exciting" but said they "do not mean that people with cancer should start using statins in the hopes of improving their progress."

The study, published Wednesday in the New England Journal of Medicine, did not look at whether the statins, with familiar brand names such as Lipitor and Mevacor, can prevent cancer - only at what happens once cancer is diagnosed.

Using multiple registries containing data on cancer, drug use, population characteristics and deaths for the nation of Denmark, the research team analyzed the cancer cases of 18,721 people over age 40 who were diagnosed between 1995 and 2007.

All were taking statins regularly before their cancer was discovered, and the study compared them to 277,204 people who had not regularly taken the drugs before getting cancer treatments.

Overall, the cancer death rate among statin users was 15 percent lower, and so was the rate of death from any cause.

The appearance of a benefit from taking statins was strongest for 13 cancer types in particular, ranging from an 11 percent lower death rate among pancreatic cancer patients to a 36 percent lower rate among cervical cancer patients. For 14 other tumor types, the results were less clear-cut.

The study's senior author, Dr. Stig Bojesen of the University of Copenhagen compared the difference in mortality to that seen with chemotherapy. "The benefit of receiving chemotherapy versus not receiving chemotherapy is 15 percent to 20 percent, depending on cancer type," he told Reuters Health. "What we see (in the new study) is comparable to that. That's really something."

The fact that a seeming benefit from statins was not seen in people taking chemotherapy, however, doesn't mean that people should avoid chemotherapy treatment and turn to statins instead, Bojesen stressed.

Rather, he thinks therapeutic use of statins might be considered when no good chemotherapy option is available for a particular cancer type.

And, if his team's finding is confirmed in a larger study, statins may offer an easy, inexpensive way to reduce cancer deaths in some patients, he added.

Because the drugs are available in generic form, "The daily cost is about 10 cents or something like that. It's extremely cheap," Bojesen said.