Side effects persist after prostate cancer treatment

Men who are treated for prostate cancer may still suffer side effects from treatment up to a decade later, a new study finds.

Researchers found that more than 500 men with cancer - including cancers caught through regular screening - ended up with poorer sexual function and more bladder control problems for up to 10 years afterward than men with no cancer diagnosis.

That might sound like a good tradeoff for having your cancer found and treated.

But the issue is complicated. Prostate cancer is often slow-growing and may never get to the point that it threatens a man's life.

And a number of studies have found no proof that using PSA blood tests to screen men for prostate cancer actually saves lives.

Because of that the U.S. Preventive Services Task Force (USPSTF) - an expert panel with federal support - advises against routine prostate cancer screening.

With the benefits of screening in doubt, that makes the question of treatment side effects even more important.

"The reality is that right now, the screening decision and the treatment decision have to be made on an individual basis," said Kathryn L. Taylor, of the Lombardi Comprehensive Cancer Center at Georgetown University in Washington, D.C.

"This study doesn't answer those questions for individuals," said Taylor, who led the research.

But she said the findings do give men more information on the long-term side effects of prostate cancer treatment - whether it's surgery, radiation or hormone therapy.

Up to 10 years after treatment, more than 95 percent of men had some degree of sexual dysfunction, Taylor's team found. And about half had urinary symptoms.

Past studies have found such lingering side effects, too. But they have been shorter-term - following men for as far as five years. And they've left some question as to whether the sexual and urinary problems could just be a product of aging, rather than prostate cancer treatment, Taylor explained.

These latest findings, reported in the Journal of Clinical Oncology, suggest it's not simply the aging process that's to blame.

That's because Taylor's team had data on men who'd taken part in a large clinical trial on prostate cancer screening.

The researchers were able to compare 269 men who'd had prostate cancer detected and treated after screening with 260 men who'd also been screened but remained cancer-free.

And when they accounted for the men's age, overall health and other factors, the group treated for cancer had worse sexual and urinary function up to 10 years later.

The same pattern held up among men in the trial arms who weren't screened for prostate cancer and did or didn't get diagnosed and treated.