Pancreatic cancer affects blacks at higher rates

Regardless of risk factors linked to pancreatic cancer, such as smoking and body mass index (BMI), blacks experienced higher rates of pancreatic cancer death than whites.

"Reducing overweight/obesity and smoking will help reduce pancreatic cancer overall, as well as prevent other diseases," said Lauren D. Arnold, Ph.D., M.P.H., postdoctoral research associate in the department of surgery at Washington University in St. Louis.

"We still have a long way to go towards understanding pancreatic cancer disparities."

Results of this cohort study are published online in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research.

Pancreatic cancer is a rapidly fatal disease that is challenging for researchers to study and treat. Because there are no good screening tests and symptoms do not often appear until the disease has spread, Arnold said that most people die within two years of diagnosis.

Statistically, pancreatic cancer claims the lives of black Americans more so than whites — between 2001 and 2005, blacks had a 32 percent higher death rate, according to background information in the study obtained from the National Cancer Institute statistics.

Arnold and colleagues examined risk factors for pancreatic cancer and separately evaluated them among black and white participants. Using data from the Cancer Prevention Study II (CPS-II), they assessed whether these risk factor patterns explained differences in incidence and mortality. CPS-II is a longitudinal study that originally enrolled more than one million participants in 1982. Participants provided information such as race/ethnicity, medical history and health habits. The researchers tracked cancer deaths in the CPS-II and evaluated the outcomes.

Regardless of gender and race, findings showed that smoking was the biggest risk factor for pancreatic cancer. Increasing risk of pancreatic cancer was associated with increasing BMI. When considered by race, blacks had a 42 percent increased risk of pancreatic cancer death compared to whites.

Excess risk of disease remained, even when the researchers eliminated all other risk factors from the calculation.

"We hoped to find that by accounting for known and suspected pancreatic cancer risk factors, such as smoking, diabetes and BMI, and by looking at this in the context of race and gender, we'd be able to explain the higher rates of pancreatic cancer in blacks," Arnold said. "Unfortunately, we were unable to explain these differences."

Maria Elena Martinez, Ph.D., M.P.H., said although differences in risk factor patterns were shown, overall, they did not account for the pancreatic cancer mortality rates evident by race. Martinez is the Richard H. Hollen Professor of Cancer Prevention at the University of Arizona, director of the Cancer Health Disparities Institute at the Arizona Cancer Center, and an editorial board member for Cancer Epidemiology, Biomarkers & Prevention.