New cancer cases rise globally, but death rates are declining in many countries

New cases of virtually all types of cancer are rising in countries globally - regardless of income - but the death rates from cancer are falling in many countries, according to a new analysis of 28 cancer groups in 188 countries.

Thanks to prevention and treatment, progress has been made in fighting certain cancers, such as childhood leukemia. But researchers found that of all the cancers studied, there was just one - Hodgkin lymphoma - where the number of new cases dropped between 1990 and 2013. Over the same period, age-standardized death rates for all cancers fell in 126 out of 188 countries.

Published in JAMA Oncology on May 28, the study, "The Global Burden of Cancer 2013," was conducted by an international consortium of researchers led by the Institute for Health Metrics and Evaluation (IHME) at the University of Washington.

In 2013, there were 14.9 million new cancer cases and 8.2 million cancer deaths worldwide. The leading cause of cancer incidence for men was prostate cancer, which caused 1.4 million new cases and 293,000 deaths. Prostate cancer cases have increased more than threefold during this period due in part to population growth and aging.

For women, similar factors contributed to the rise in breast cancer incidence. In 2013 there were 1.8 million new cases of breast cancer and 464,000 deaths. Breast cancer has remained the leading cause of incident cancer cases for women between 1990 and 2013, but the number of new cases doubled during this period.

Other leading causes of incident cases globally include colon and rectum cancers, which have increased 92%, stomach cancer, up 23% since 1990, and liver cancer, with a 70% increase.

"Cancer remains a major threat to people's health around the world," said oncologist Dr. Christina Fitzmaurice, a Visiting Fellow at IHME and lead author of the study. "Cancer prevention, screening, and treatment programs are costly, and it is very important for countries to know which cancers cause the highest disease burden in order to allocate scarce resources appropriately."

The death toll from cancer is also changing as new cases increase. Cancer was the second-leading cause of death globally after cardiovascular disease, and the proportion of deaths around the world due to cancer has increased from 12% in 1990 to 15% in 2013. Lung, stomach, and liver cancer have remained the three leading causes of cancer deaths for both sexes combined during this time period. Lung cancer deaths have increased by 56%, stomach cancer deaths by 10%, and liver cancer deaths by 60%.

Cancer is often seen as a problem primarily in more affluent nations, but the disease is an issue in developing countries as well as developed countries. Even though breast cancer remains the leading cause of incident cancer cases for women globally, in developed countries incidence rates have been stable or declining since the early 2000s. The reverse is true in developing countries, where incidence rates are lower but rising faster than in developed countries.