Ginkgo biloba reduces aggressive cancer risk in animal experiments

Researchers at Georgetown University Medical Center say they now have a clearer picture of how an extract from the leaves of the Ginkgo biloba tree reduces the risk of aggressive cancer in animal experiments.

In the January-February issue of the journal Anticancer Research, the investigators reported that treating mice with an extract of leaves of Ginkgo biloba both before and after implanting human breast or brain (glioma) tumors decreased expression of a cell receptor associated with invasive cancer. This decreased expression slowed the growth of the breast tumors by 80 percent as long as the extract was used, compared to untreated mice, and also reduced the size of the brain tumors, but temporarily, and to a lesser extent.

Ginkgo biloba extract is a popular supplement that comes from the leaves of the Gingko tree, which is indigenous to Japan, Korea and China but can be found all over the world.

Many believe it enhances memory, and is being currently being tested as a treatment for Alzheimer's disease.

"It is very encouraging that Ginkgo biloba appeared to reduce the aggressiveness of these cancers, because it suggests that the leaves could be useful in some early stage diseases to prevent them from becoming invasive, or spreading," said the study's senior author, Vassilios Papadopoulos, DPharm, PhD, Director, Biomedical Graduate Research Organization and Associate Vice President of Georgetown University Medical Center.

"But I must stress that this is a study in mice, and so we cannot say what anticancer effects, if any, Gingko biloba might offer humans," he said.

Papadopoulos and his research team became interested in Gingko biloba because their research suggested that it might interact with the peripheral-type benzodiazepine receptor (PBR), a molecule they have been studying for the last 20 years. For example, they have determined that this protein (discovered by accident when researchers looked at how the anti-anxiety drug diazepam, better known as Valium., worked) is involved in bringing cholesterol into a cell's mitochondria.

In some cells the mitochondria uses cholesterol to produce steroids, which are regulatory hormones that, among other functions, help a cell grow, Papadopoulos said. "In fact, we have found that most life forms, including plants, insects, and animals, have receptors like these that help regulate growth."

So they looked at whether cancer cells - with their need to proliferate - produce more of these cholesterol-bearing receptors, and found that some highly invasive cancers do, indeed, over-express PBR. "Accelerated growth requires production of new cell membranes, and one of the main components of membranes is cholesterol," Papadopoulos said.

The researchers also knew that steroids help regulate brain function, and they found over-expression of PBR is also associated with a variety of neurological disorders. Because the leaf of Ginkgo biloba is an ancient Chinese treatment for dementia that is still widely used - and which is now being tested in the U.S. to treat Alzheimer's disease patients - Papadopoulos decided to look at the effect of Ginkgo biloba on PBR production.