Study finds long nerve grafts restore function in patients with brachial plexus injury

A study by researchers at Hospital for Special Surgery (HSS) challenges a widely held belief that long nerve grafts do poorly in adults with an axillary nerve injury. Investigators found that the outcomes of long nerve grafts were comparable to those of modern nerve transfers. Both procedures restored function. The axillary nerve supplies the deltoid muscle of the shoulder and an important rotator cuff muscle. It's part of the brachial plexus, a network of nerves that runs down from the neck and across the shoulder.

"Conventional wisdom is that grafts longer than seven centimeters (about three inches) don't work well. We set out to test this theory and found that long nerve grafts did work well. Our study concludes that this type of graft should not be overlooked as an effective treatment for an axillary nerve injury," said Dr. Scott W. Wolfe, lead author and director of the Center for Brachial Plexus and Traumatic Nerve Injury at Hospital for Special Surgery in New York City.

The study, titled, "Comparison between Long Nerve Grafts and Nerve Transfers for Axillary Nerve Injuries," will be presented at the annual meeting of the American Academy of Orthopaedic Surgeons on March 22 in Chicago.

Injury to the brachial plexus can be devastating, leaving people unable to use their arms or hands. The most common cause is a motor vehicle accident or sports injury. The Center for Brachial Plexus and Traumatic Nerve Injury at Hospital for Special Surgery offers advanced diagnostic and treatment options, including complex nerve reconstruction surgery.

Nerve reconstruction is considered when nerves are so severely damaged they cannot recover on their own. These complex operations can take up to 12 hours. Surgeons reconstruct nerves either by bridging a nerve defect with a nerve graft or by performing a nerve transfer from a nearby healthy nerve to share its function. In the study, researchers compared these two different techniques to reactivate the deltoid muscle and enable patients to regain the use of their arm.

"A nerve transfer takes a working nerve from one muscle and transfers all or part of that nerve to a non-working nerve or another muscle, so that the two muscles can share the nerve and regain function," Dr. Wolfe explained. "A nerve graft involves taking a nerve from another part of the body. The nerve is removed from a location where its function is less important, usually the leg, and moved to the damaged area. It is used to bridge the defective gap between two ends of a nerve to restore function."

Only 150 to 200 highly specialized surgeons worldwide perform these complex brachial plexus surgeries, and Dr. Wolfe and his colleagues aim to raise awareness that the procedures can restore function in people severely debilitated by a nerve injury. It is important for patients to be treated in a timely manner.

Traditionally, nerve grafts longer than seven centimeters have demonstrated worse outcomes than short grafts and poorer functional outcome when compared to nerve transfer surgery. The purpose of the HSS study was to take another look at longer grafts and directly compare the outcomes to nerve transfers. The results were measured by the patients' recovery and by a test called electromyography, or EMG. This sophisticated test is used to objectively measure muscle and nerve function.