Possible Causes of Disturbances

During the transition from menarche to a normal ovulatory cycle, a number of influences and noxae may cause…    

Menstrual Irregularities

Evidence-Based Clinical Practice
The establishment of a regular menstrual cycle is an important process for an…    

Development of the Menstrual Cycle

Sexual development in puberty begins with activation of the gonadotropinreleasing hormone (GnRH) pulse generator and the hypothalamic-pituitary system.…    

Clinical Importance of Menstrual Irregularities

Abnormalities of the type of bleeding may be a serious problem for adolescent girls. Menorrhagia or metrorrhagia are…

Primary Amenorrhea with Developed Secondary Sex Characteristics

In cases of partially or completely developed secondary sexual characteristics, patients will refer to the physician for primary…    

Hyperandrogenia

Sexual ambiguities have been diagnosed during the neonatal period.
However, pubertal development may be associated with…    

Therapeutic Aspects

Treatment of delayed puberty and/or primary amenorrhea requires precise etiological diagnosis, determination of bone age and evaluation of…    

Constitutional Delay in Growth and Puberty (CDGP)

Delayed puberty as described earlier has a statistical definition based on epidemiological studies. Onset of development, which includes…    

Isolated Idiopathic IHH

Impaired Pulsatile Secretion of LHRH
In absence of anosmia, the Kal gene is not involved, as…    

Congenital Gonadotropin Deficiency

Primary gonadotropin deficiency is associated with very low levels of FSH and LH, concordant bone age, normal stature…    

Iatrogenic Ovarian Failure

Prepubertal girls treated with radiation therapy or chemotherapy may present gonadal failure with delayed puberty or primary or…    

Non-Tumoral Acquired Organic Lesions of CNS

- Histiocytosis X (Hans-Schüller-Christian disease) is characterized by multiple organ infiltration (skin, bone, viscera) by histiocytic cells.…    

Acquired IHH

Organic Direct Gonadotropin Deficiency
To establish etiological diagnosis, complete medical history and clinical exam are associated…    

Karyotypically Normal 46,XX Ovarian Dysgenesis

Ovarian dysgenesis with a normal 46,XX karyotype is defined by reduced or altered ovaries, a female phenotype, and…    

Delayed Puberty Clinical Aspects

Initial evaluation, based on a detailed history and complete clinical exam, will establish undeveloped, partially or completely developed…    

Delayed Puberty Etiological Aspects

Actually, after this clinical exam and these simple complementary investigations, the physician often has a presumptive diagnosis. The…    

Delayed Puberty Epidemiological Aspects

Age at onset of puberty varies greatly among individuals and populations and seems to be influenced by both…    

Delayed Puberty Physiological Aspects

Increase in the pulsatile release of LHRH is a necessary condition for puberty onset, as demonstrated 22 years…    

Delayed Puberty

Developmental changes during puberty in girls occur over a period of 3 - 5 years, usually between 9…    

Too many babies too close together can shorten a woman’s life

According to researchers women who have their babies very close together, along with women who never have children,…